Migraines can have
different triggers for different people — including
foods, emotions, lack of sleep, etc. By learning to identify
your personal triggers,
you can help control your own migraines.
Some of the more common migraine triggers include:
Emotional Stress – Certain brain
chemicals, such as serotonin, are thought to
play an important role in migraines. This is why anxiety,
depression, or general stress can set off a migraine attack.
Reactions to Food – Up
to 30% of migraines may be caused by reactions
to certain types of
foods or beverages. Some of the more common are:
Nitrates: Found in hot dogs, lunch meats, and most
prepared meats like pepperoni
Monosodium Glutamate (MSG): Commonly found in Chinese
food.
Caffeine: Although caffeine
consumption can actually
help with migraine pain,
caffeine is addictive – and
withdraw can lead to the onset of a migraine
Changes in Weather – Although
uncommon, some people can get migraines
during barometric pressure
changes
Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of dihydroergotamine with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum levels of dihydroergotamine, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated.
Migranal Nasal Spray should not be given to patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia) or to patients who have clinical symptoms or findings consistent with coronary artery vasospasm, including Prinzmetal's variant angina. Migranal also should not be given to patients with uncontrolled hypertension, patients who have used 5-HT1 agonists, ergotamine-containing or ergot-type medications or methysergide within the last 24 hours, or patients with hemiplegic or basilar migraine. Migranal Nasal Spray is also contraindicated in patients with known peripheral arterial disease, sepsis, following vascular surgery, and severely impaired hepatic or renal function. Migranal Nasal Spray should not be administered to pregnant women or nursing mothers.
Serious cardiac events, including some that have been fatal, have occurred following use of DHE 45 but are extremely rare. During clinical studies and the foreign postmarketing experience with Migranal Nasal Spray, there have been no fatalities due to cardiac events.
The most commonly reported adverse events in clinical trials for Migranal Nasal Spray were rhinitis, altered sense of taste, application site reactions, dizziness, nausea and vomiting. Adverse events associated with discontinuation were rhinitis, dizziness, facial edema, cold sweats, accidental trauma, depression, elective surgery, somnolence, allergy, vomiting, hypotension, and paresthesia.
Common Migraine Triggers 
