As anyone who has ever experienced a migraine
knows, it’s more than just a bad headache. In addition
to terrible pain, migraines can affect your eyesight, make
you sensitive to sound and light, make you nauseous, and even
lead to vomiting.
Migraines affect a lot of Americans – almost 28 million – so
it’s
important to remember that you are not alone. Additionally, almost half of
all migraine sufferers have attacks so bad that their daily activities are
disrupted. This can mean missing work, school, or even part of a vacation.
Use this section to learn more about migraines as well as what you can do to
find relief.
Serious and/or life-threatening peripheral ischemia has been associated with the coadministration of dihydroergotamine with potent CYP3A4 inhibitors including protease inhibitors and macrolide antibiotics. Because CYP3A4 inhibition elevates the serum levels of dihydroergotamine, the risk for vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Hence, concomitant use of these medications is contraindicated.
Migranal Nasal Spray should not be given to patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia) or to patients who have clinical symptoms or findings consistent with coronary artery vasospasm, including Prinzmetal's variant angina. Migranal also should not be given to patients with uncontrolled hypertension, patients who have used 5-HT1 agonists, ergotamine-containing or ergot-type medications or methysergide within the last 24 hours, or patients with hemiplegic or basilar migraine. Migranal Nasal Spray is also contraindicated in patients with known peripheral arterial disease, sepsis, following vascular surgery, and severely impaired hepatic or renal function. Migranal Nasal Spray should not be administered to pregnant women or nursing mothers.
Serious cardiac events, including some that have been fatal, have occurred following use of DHE 45 but are extremely rare. During clinical studies and the foreign postmarketing experience with Migranal Nasal Spray, there have been no fatalities due to cardiac events.
The most commonly reported adverse events in clinical trials for Migranal Nasal Spray were rhinitis, altered sense of taste, application site reactions, dizziness, nausea and vomiting. Adverse events associated with discontinuation were rhinitis, dizziness, facial edema, cold sweats, accidental trauma, depression, elective surgery, somnolence, allergy, vomiting, hypotension, and paresthesia.
As anyone who has ever experienced a migraine
knows, it’s more than just a bad headache. In addition
to terrible pain, migraines can affect your eyesight, make
you sensitive to sound and light, make you nauseous, and even
lead to vomiting. 
